業績・研究内容

膵島移植、移植免疫、糖尿病

  • Beneficial effects of activated protein C on amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving intrahepatic syngenic islets from a single donor. 福岡大学医学紀要 36(2)103-112, 2009  Nakano M, Mera T, et al.
  • Prevention of early loss of transplanted islets in the liver of mice by adenosine.
    Transplantation. 88(1):49-56, 2009  T Nitta, T Mera, et al.
  • High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice.
    J Clin Invest. 120(3):735-743, 2010  N Matsuoka, T Mera, et al.
  • (特集)膵臓・膵島移植の現状と最新の研究;移植早期膵島障害機序の解明と新規制御法開発.
    膵臓. 26(2): 183-189, 2011  米良利之、小玉正太、安波洋一
  • Prevention of High-Mobility Group Box 1-Mediated Early Loss of Transplanted Mouse Islets in the Liver by Antithrombin III. 93(10): 983-88, 2012  Kojima D, Mera T, et al.
  • Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation. Am J Transplant. 13(8): 2154-60, 2013
    Mera T, et al.
  • HMGB1-Mediated Early Loss of Transplanted Islets Is Prevented by Anti-IL-6R Antibody in Mice.
    Pancreas. 2014 Jul 23. Itoh T, Mera T, et al.
  • Removal of donor human leukocyte antigen class I proteins with papain: translation for possible whole organ practices.
    Transplantation. 2015 Apr;99(4):724-30.  Mera T, Faustman DL.
  • Pretreatment of donor islets with papain improves allograft survival without systemic immunosuppression in mice.
    Islets. 2016 Sep 2;8(5):145-55.  Kumano K, Mera T, et al.

内分泌疾患

  • The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren’s syndrome. Laboratory investigation. 93(11):1203-18, 2013 Enger TB Mera T, et al.
  • Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells.
    Heliyon. 2018 May17;4(5)  Tanaka T, Mera T, et al.

免疫、Treg、抗体作製

  • Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2
    Scientific Reports. 2013.Nov.6   Yoshiaki Okubo, Toshiyuki Mera, et al.
  • Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs.
    Sci Signal. 2017 Jan 17;10(462).  Torrey H, Mera T, et al.

大腸癌、化学療法、免疫治療

  • Adoptive Chemoimmunotherapy Using Activated αβ T Cells for Stage IV Colorectal Cancer.
    Anticancer Res. 2016 Jul;36(7):3741-6. Yoshida Y, Mera T, et al.
  • Objective evaluation of oxaliplatin-induced vascular pain secondary to peripheral vein administration.
    Springerplus. 2016 Oct 26;5(1):1872. Yoshida Y, Mera T, et al.
  • Difference in Neutropenia due to Administration Schedule of TAS-102.
    Case Rep Oncol. 2017 Mar 2;10(1):226-229.  Yoshida Y, Mera T, et al.
  • Hepatectomy for Liver Metastases of Colorectal Cancer After Adoptive Chemoimmunotherapy Using Activated αβ T-cells.
    Anticancer Res. 2017 Jul;37(7):3933-3939. Ishii F, Mera T, et al.
  • Clinical Study on the Medical Value of Combination Therapy Involving Adoptive Immunotherapy and Chemotherapy for Stage IV Colorectal Cancer (COMVI Study).
    Anticancer Res. 2017 Jul;37(7):3941-3946. Yoshida Y, Mera T, et al.
  • Phase II study on early start of chemotherapy after excising primary colorectal cancer with distant metastases (Pearl Star 02).
    Ann Gastroenterol Surg. 2017 Aug 14;1(3):219-225  Yoshida Y, Mera T, et al.
  • 消化管分泌腫瘍診療ガイドラインの解説 胃と腸 2017 52 4 450-453 医学書院  長谷川 傑、米良利之、他
  • 大腸の腹腔鏡下手術 高位前方切除術 特集:エキスパートはここにこだわる!
    胃癌・大腸癌に対する腹腔鏡下手術 消化器外科 2017 40 3 325-331 へする出版  小島大望、米良利之、他